Andrew Bergen, Ph.D., Senior Scientist
Contact
Education & Training
B.A., 1984
Haverford College, Haverford, PA
Biology
M.A., 1992
Johns Hopkins University, Baltimore, MD
Human Genetics
Ph.D., 1996
George Washington University, Washington, DC
Genetics
Dr. Bergen's research spans aging, psychiatric and substance use disorders, and relies upon collaboration with colleagues and institutions from multiple sectors.
Dr Bergen and colleagues have demonstrated effects of combined use of prescription analgesics and sedatives and the use of prescription analgesics on frailty in the Health and Retirement Study. Dr Bergen contributes to the Price Foundation (eating disorders) and Psychiatric Genomics consortia. Dr Bergen has led or contributed to pharmacogenetic meta-analyses of cessation trials, genomic meta-analyses of smoking behaviors and prediction modeling of the nicotine metabolite ratio in multiethnic cohorts, and analyses of time-dependent effects of buprenorphine treatment in opioid use disorder treatment trials.
Current Projects
Smokescreen Translational (TL) Analysis Platform
PROJECT PERIOD09/01/18 - 08/31/21 FUNDING AGENCYNational Institute of Alcohol Abuse and Alcoholism (NIAAA) CURRENT STATUSCompleted TEAMPrincipal Investigator |
Salivary Biomarkers (DNA, RNA and Cortisol), Life Stress and Nicotine Dependence
PROJECT PERIOD09/30/09 - 08/31/12 FUNDING AGENCYNational Institute on Drug Abuse (NIDA) CURRENT STATUSCompleted TEAMPrincipal Investigator |
Publications
Saunders, G. R. B. et al. (2022). Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature; published online Dec 7 2022.
Baurley JW, Bergen AW, Ervin CM, Park SL, Murphy SE, McMahan CS. Predicting nicotine metabolism across ancestries using genotypes. BMC Genomics. 2022 Sep;23(1):663.
Complete list of published work in MyBibliography
Gouveia MH, Otim I, Ogwang MD, Wang M, Zhu B, Cole N, … Mbulaiteye SM. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility. Leukemia. 2021 Apr;35(4):1209-1213
Bergen, AW, McMahan, CS, McGee, S, Ervin, CM, Tindle, HA, Le Marchand, L., Murphy, DO, Patel, YM, Park, SL, & Baurley, JW (2021) Multiethnic Prediction of Nicotine Biomarkers and Association with Nicotine Dependence. Nicotine Tob Res. 2021 Nov;23(12):2162-2169.
Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, … Agrawal A. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addict Biol. 2021 Jan;26(1):e12880.
Gouveia MH, Borda V, Leal TP, Moreira RG, Bergen AW, Kehdy FSG, … Tarazona-Santos E. Origins, admixture dynamics, and homogenization of the African gene pool in the Americas. Mol Biol Evol. 2020 Jun 1;37(6):1647-1656.
Duffy ME, Rogers ML, Joiner TE, Bergen AW, Berrettini W, Bulik CM, … Keel PK. An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses. Int J Eat Disord. 2019 Feb;52(2):200-205.
Gouveia, M. H., Bergen, A. W., Borda, V., Nunes, K., Leal, T. P., Ogwang, M. D., ... Mbulaiteye, S. M. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genet. 2019 Mar 8;15(3).1008027
Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A. ... Bulik, C. M. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet. 2019 Aug;51(8):1207-1214.
Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11.
Cil G, Park J, Bergen AW. Self-reported prescription drug use for pain and for sleep and Incident frailty. J Am Geriatr Soc. 2019 Dec;67(12):2474-2481.
Panagiotou OA, Schuit E, Munafò MR, Bennett DA, Bergen AW, David SP. Smoking cessation pharmacotherapy based on genetically-informed biomarkers: What is the evidence? Nicotine Tob Res. 2019 Aug;21(9):1289-1293.
Bergen AW, Do EK, Chen L-S, David SP. Tobacco genomics: Complexity and Translational Challenges. Nicotine Tob Res. 2019 Apr 21(6):705-706.
The Brainstorm Consortium, et al. Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395).
Bergen, AW. Biomarkers for tobacco exposures, toxicology, regulation and cessation. Nicotine Tob Res. 2018 Mar 6;20(4):401-402.
Baurley JW, McMahan CS, Ervin CM, Pardamean B, Bergen AW. Biosignature discovery for substance use disorders using statistical learning. Trends Mol Med. 2018 Feb;24(2):221-235.
Johansson JU, Brubaker WD, Javitz H, Bergen AW, Nishita D, Trigunaite A, ... Rogers J. Peripheral complement interactions with amyloid β peptide (Aβ) in Alzheimer’s disease: polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement. 2018 Nov;14(11):1438-1449.
Hinney A, Kesselmeier M, Jall S, Volckmar A-L, Föcker M, Antel J, ... Hebebrand J. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017 Feb;22(2):192-201.
Schuit E, Panagiotou OA, Munafò MR, Bennett DA., Bergen AW, David SP. Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. Cochrane Database Syst Rev. 2017 Sep 8;9:CD011823.
Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V. ... Bulik, C. M. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry. 2017 Sep 1;174(9):850-858.
Schwantes-An, T. H., Zhang, J., Chen, L.-S., Hartz, S. M., Culverhouse, R. C., Chen, X., ... Saccone, N. L. Association of the OPRM1 variant rs1799971 (A118G) with non-specific liability to substance dependence in a collaborative de novo meta-analysis of European-ancestry cohorts. Behav Genet 2016 Mar;46(2):151-69.
Shih, P. B, Yang, J., Morisseau, C., German, J. B., Zeeland, A. A., Armando, A. M., ... Kaye, W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry 2016 Apr;21(4):537-46.
David, S. P., Wang, A., Kapphahn, K., Hedlin, H., Desai, M., Henderson, M., ... Stefanick, M. L. Gene by environment investigation of incident lung cancer risk in African-Americans. (2016). EBioMedicine 2016 Jan 11;4:153-61.
Baurley, JW, Edlund, CK, Pardamean, C,, Conti, DV, Krasnow, R, Javitz, HS, Hops H, Swan GE, Benowitz NL ... Bergen, AW. Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries. Nicotine Tob Res 2016 Sep;18(9):1837-44.
Guo, Y., Wei, Z., Keating, B. J.; Genetic Consortium for Anorexia Nervosa; Wellcome Trust Case Control Consortium; Price Foundation Collaborative Group, & Hakonarson, H. Machine learning derived risk prediction of anorexia nervosa. BMC Med Genomics 2016 Jan 20;9:4.
Baurley, J. W., Edlund, C. K., Pardamean, C. I., Conti, D. V., Bergen, A. W. Smokescreen: a targeted genotyping array for addiction research. BMC Genomics 2016 Feb 27;17:145.
Bergen, A. W., Krasnow, R., Javitz, H. S., Swan, G. E., Li, M. D., Baurley, J. W., Chen, X., Murrelle, L., & Zedler, B. Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures (2015). BMC Public Health. 2015 Sep 7;15:866.
Experience
2021-present Member, Scientific Development Funds Policy Committee, Oregon Research Institute, Eugene, OR
2021-present Member, Growth and Innovation Fund Distribution Committee, Oregon Research Institute, Eugene, OR
2021-present Consultant, Rutgers, New Jersey Medical School, Newark, NJ
2019-2022 Board Member, Oregon Research Institute, Eugene, OR
2019-2020 Member, multiple Growth and Innovation Task Forces, Oregon Research Institute, Eugene, OR
2018-present Member, Growth and Innovation Advisory Group, Oregon Research Institute, Eugene, OR
2018-present Consultant, BioRealm, LLC Walnut, CA
2018-2022 Member, Mental Health Advisory/Local Alcohol and Drug Planning Committee, Lane County Board of Commissioners, Lane County, OR
2018-2021 MPI, R44AA027675 Smokescreen Translational (TL) Analysis Platform MPIs: Baurley & Bergen
2018 MPI, R43 DA046325 Biosignatures of Opioid Addiction Treatment Success MPIs: Baurley & Bergen
2017-present Senior Scientist, Oregon Research Institute Eugene, OR
2017 Consultant, Westat, Inc. Rockville, MD
2017 Consultant, Granite Point Ventures Greenbelt, MD
2016 MPI, R43 DA041211 Smokescreen Translational (TL) Analysis Platform MPIs: Baurley & Bergen
2015-2018 Associate, BioRealm LLC Walnut, CA
2015-2018 Member, Pharmacogenomics of Nicotine Addiction Treatment Research Group
2014-2021 Member, Tobacco Addiction Group Cochrane Collaboration
2014-present Member, Psychiatric Genomics Consortium
2014-present Scientific Advisor, BioRealm, LLC Walnut, CA
2014 Center for Tobacco and Alcohol Studies Visiting Professorship, School of Experimental Psychology University of Bristol UK
2012-2015 PI, R21 DA033813 DMET Genes, Nicotine Metabolism and Prospective Abstinence
2011 Statistical Analysis of Genome Scale Data, Cold Spring Harbor Laboratory Cold Spring Harbor, NY
2009-2012 MPI, RC2DA028793 Salivary Biomarkers, Life Stress and Nicotine Dependence MPIs: Andrews & Bergen
2009-2011 Co-I, R01 CA071358 Treatment of Nicotine Dependence in a Health Care Setting PI: Swan
2009-2010 Research Steering Committee Member Metabolic SNPs and Nicotine and Cotinine Metabolism in Two Family Based Samples
(Medco Health Solutions and Affymetrix, Members: Bergen & Swan)
2008-2009 Research Steering Committee Member, Resequencing Candidate Genes of Interest in Nicotine Dependence
(Perlegen BioSciences, Members: Bergen & Swan)
2007-2015 Director, Program in Molecular Genetics Center for Health Sciences, SRI International Menlo Park, CA
2007-2014 Co-I, U01 DA020830 Pharmacogenetics of Nicotine Addiction Treatment MPIs: Benowitz, Lerman, & Tyndale
2007-2009 Co-I, P50 CA084735 Genes, Environment & Tobacco Use Across Cultures PI: Johnson
2002-2007 Staff Scientist, Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda, MD
2002-2006 Adjunct Assistant Professor, Epidemiology and Biostatistics, George Washington University Washington, DC
2002-2006 Principal, Andrew W. Bergen, LLC
1999-present Co-Investigator, Environment and Genetics in Lung Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute Rockville, MD
1999-2001 Co-Founder, Laboratory Director, & Vice President, Biognosis U.S., Inc. Gaithersburg, MD
1998 Twin and Family Studies Workshop Institute for Behavioral Genetics, University of Colorado Boulder, CO
1998 Genetic-Epidemiologic Studies of Complex Diseases Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
1997-1999 Cancer Genetics and Epidemiology Post-Doctoral Fellowship, National Cancer Institute Rockville, MD
1996-1997 Post-Doctoral IRTA Fellowship, National Institute of Alcoholism and Alcohol Abuse Rockville, MD
1993-1996 Pre-Doctoral IRTA Fellowship, National Institute of Alcoholism and Alcohol Abuse Rockville, MD
1989 Mammalian Genetics Jackson Laboratory Bar Harbor, ME
1988-1991 NIH Pre-Doctoral Training Award, Johns Hopkins University Baltimore, MD
1987-1988 Research Associate, Cellmark Diagnostics Germantown, MD
1985-1987 Research Technician, Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University Baltimore, MD
Recent Research
Substance Use Disorders
Nature s41586-022-05477-4 Genetic Diversity Fuels Gene Discovery for Tobacco and Alcohol Use
PubMed 35409790 Effects of Buprenorphine Dose and Therapeutic Engagement on Illicit Opiate Use
PubMed 34313775 Multiethnic Prediction of Nicotine Biomarkers and Association with Nicotine Dependence
Eating Disorders
PubMed 32064741 Genetic Correlations Between Eating and Substance Use Disorders
PubMed 31835028 Genomic Relationships, Novel Loci, and Pleiotropy across Psychiatric Disorders
PubMed 31308545 Meta-GWAS of Anorexia Nervosa, Psychiatric Genomics Consortium (PGC-EDWG)
Aging
PubMed 35590086 Frailty Risks of Prescription Analgesics and Sedatives
PubMed 31648384 Prescription Drug Use for Pain and for Sleep and Incident Frailty
PubMed 29792870 Erythrocyte Complement Receptor 1 Deficiency and Alzheimer’s Disease
Global Health
PubMed 32128591 Contributions of the African Gene Pool to the Americas
PubMed 30849090 Gene flow and selection in populations of the "endemic Burkitt Lymphoma belt"
PubMed 29033373 Mendelian Randomization, beta hemoglobin and endemic Burkitt Lymphoma